Preferred Label : STING Agonist GSK3745417;
NCIt definition : An agonist of the stimulator of interferon genes protein (STING; transmembrane protein
173; TMEM173), with potential immunoactivating and antineoplastic activities. Upon
intravenous administration, STING agonist GSK3745417 targets and binds to STING and
activates the STING pathway in immune cells in the tumor microenvironment (TME). This
leads to the production of pro-inflammatory cytokines, including interferons (IFNs),
enhances the cross-presentation of tumor-associated antigens (TAAs) by dendritic cells
(DCs), and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against
cancer cells. STING, a transmembrane protein that activates immune cells in the TME,
plays a key role in the activation of the innate immune system.;
Molecule name : GSK 3745417; GSK-3745417;
NCI Metathesaurus CUI : CL978866;
Origin ID : C165748;
UMLS CUI : C5237425;
Semantic type(s)
- concept_is_in_subset
- has_target
