Preferred Label : Anti-Globo H/MMAE Antibody-drug Conjugate OBI 999;
NCIt synonyms : Anti-Globo H/MMAE ADC OBI 999; ADC OBI 999; OBI-888/MMAE ADC OBI-999;
NCIt definition : An antibody-drug conjugate (ADC) composed of OBI-888 (OBI 888), a humanized monoclonal
antibody directed against the tumor-associated antigen (TAA) globohexaosylceramide
(globo H), covalently linked to monomethyl auristatin E (MMAE), an auristatin derivative
and a potent microtubule disrupting agent, with potential antineoplastic activity.
Upon administration of anti-globo H/MMAE ADC OBI 999, the antibody moiety of OBI 999,
OBI 888, targets and binds to globo H on tumor cells and is rapidly internalized,
thereby delivering MMAE intracellularly. Upon proteolytic cleavage, MMAE targets and
binds to tubulin and inhibits its polymerization, resulting in G2/M checkpoint arrest
and apoptosis in globo H-expressing tumor cells. Globo H, a hexasaccharide glycosphingolipid,
is (over)expressed on the surface of many types of tumor cells. Globo H is minimally
or not expressed on healthy, normal cells; its expression on cancer cells is associated
with increased proliferation and poor prognosis.;
Molecule name : OBI-999; OBI 999;
NCI Metathesaurus CUI : CL978959;
Origin ID : C165657;
UMLS CUI : C5237348;
Semantic type(s)
- concept_is_in_subset
- has_target
