Preferred Label : STING Agonist IMSA101;
NCIt definition : A small molecule analogue of cyclic GMP-AMP (cGAMP) that acts as an agonist of the
stimulator of interferon genes protein (STING; transmembrane protein 173; TMEM173)
with potential immunoactivating and antineoplastic activities. Upon intratumoral administration,
STING agonist IMSA101 binds to STING and activates STING-mediated pathways. This activates
the immune response through the activation of certain immune cells which induces the
expression of pro-inflammatory cytokines and chemokines, promotes tumor-associated
antigen (TAA) processing and presentation by dendritic cells (DCs) and leads to an
antigen-specific T-cell mediated immune response against cancer cells. STING, a transmembrane
protein that activates immune cells in the tumor microenvironment, plays a key role
in the activation of the innate immune system.;
Molecule name : IMSA-101; IMSA 101;
NCI Metathesaurus CUI : CL978957;
Origin ID : C165655;
UMLS CUI : C5237346;
Semantic type(s)
- concept_is_in_subset
- has_target
