Preferred Label : Gallium-based Bone Resorption Inhibitor AP-002;
NCIt related terms : TRIS(8-HYDROXYQUINOLINATO)GALLIUM;
NCIt definition : An orally bioavailable gallium (Ga)-based small molecule agent with potential anti-bone
resorption and antineoplastic activities. Upon oral administration, AP-002 selectively
inhibits osteoclast differentiation and bone resorption, and may promote the growth
of osteoblasts thereby improving the skeletal sequelae of bony metastases which include
pain, spinal cord compression, fractures and hypercalcemia of malignancy. Additionally,
AP-002 may, through an as of yet undescribed mechanism of action, directly target
and kill bone tumor cells.;
UNII : R3G3HB38O4;
CAS number : 14642-34-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 14642-34-3
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : AP 002; AP-002;
NCI Metathesaurus CUI : CL978946;
Origin ID : C165650;
UMLS CUI : C5237342;
Semantic type(s)
- concept_is_in_subset
