Preferred Label : Antisecretory Factor-enriched Egg Yolk Powder Supplement;
NCIt synonyms : AF-enriched Egg Yolk Powder Supplement;
NCIt definition : A dietary supplement composed of dried egg yolk powder that is highly enriched in
the protein anti-secretory factor (AF), with anti-inflammatory, anti-diarrheal, immunomodulating
and chemo-adjuvant activities. Upon intratumoral administration of the AF-enriched
egg yolk powder supplement, AF is able to normalize fluid flow by regulating the ion
and fluid balance across the cell membranes, and decreases high interstitial fluid
pressure (IFP). As elevated IFP presents a barrier to drug uptake and poor perfusion
in solid tumors, reducing IFP levels allows for increased uptake and an enhanced effect
of chemotherapeutic agents. In addition, AF may be able to modulate the immune system
and may have immunomodulatory effects on myeloid cells. It may also modulate the secretion
of immunomodulatory agents from tumor cells. In addition, AF may affect the secretion
of various pro-inflammatory mediators such as interleukin-6 (IL-6), IL-8, monocyte
chemotactic protein-1 (MCP-1; monocyte chemoattractant protein-1; C-C Motif Chemokine
Ligand 2; CCL2), macrophage inflammatory protein-1alpha (MIP-1a), and macrophage inflammatory
protein-1beta (MIP-1b). AF, a 41 kilodalton (kDa) endogenous and essential protein
secreted in plasma and other tissue fluids in mammals, is increased after exposure
to bacterial toxins and endogenous triggers of inflammation.;
Drug name : Salovum;
NCI Metathesaurus CUI : CL978952;
Origin ID : C165649;
UMLS CUI : C5237341;
Semantic type(s)
- Food [UMLS semantic type]
- concept_is_in_subset
