Preferred Label : Irradiated Allogeneic Human Lung Cancer Cells Expressing OX40L-Ig Vaccine HS-130;
NCIt definition : An allogeneic irradiated human lung cancer cell vaccine expressing a fusion protein
composed of the OX40 ligand (OX40L) linked to an immunoglobulin (Ig) (OX40L-Ig), with
potential immunomodulating and antineoplastic activities. Upon intradermal administration
of irradiated allogeneic human lung cancer cells expressing OX40L-Ig vaccine HS-130,
the irradiated lung cancer cells continuously express OX40L-Ig. OX40L may then target,
bind to and activate its cognate receptor, tumor necrosis factor receptor superfamily
member 4 (TNFRSF4; OX40; CD134), which is expressed on activated T-cells. OX40L/OX40
binding promotes increased cytokine production, and induces the proliferation and
activation of memory and effector T-lymphocytes against the human lung cancer cells.
In turn, this promotes a CTL-mediated immune response against the endogenous lung
cancer cells. OX40L, a cell surface glycoprotein and member of the tumor necrosis
factor (TNF) ligand family, provides a co-stimulatory signal for the proliferation
and survival of activated T-cells.;
Molecule name : HS 130; HS-130;
NCI Metathesaurus CUI : CL978790;
Origin ID : C165639;
UMLS CUI : C5237332;
Semantic type(s)
- concept_is_in_subset
