Preferred Label : G Protein-coupled Estrogen Receptor Agonist LNS8801;
NCIt synonyms : GPER Agonist LNS8801;
NCIt related terms : LNS-8801;
NCIt definition : An orally bioavailable selective agonist of the G protein-coupled estrogen receptor
(G protein-coupled estrogen receptor 1; GPER; GPER1; GPR30), with potential immunomodulating
and antineoplastic activities. Upon oral administration, LNS8801 targets, binds to
and activates GPER. This activates GPER-mediated signaling and suppresses the expression
of various tumor-associated genes, such as c-Myc and programmed cell death-ligand
1 (PD-L1). This leads to an inhibition of tumor cell proliferation. GPER activation
may also induce immune memory. GPER is a membrane protein and a member of the G-protein
coupled receptors (GPCRs) that are widely distributed in various tissues. GPER is
a tumor suppressor in a wide range of cell cancer types.;
UNII : TFS4QE36ZG;
CAS number : 925419-53-0;
Molecule name : LNS-8801; LNS 8801;
NCI Metathesaurus CUI : CL978801;
Origin ID : C165626;
UMLS CUI : C5237321;
Semantic type(s)
- concept_is_in_subset
- has_target
