Preferred Label : Therapeutic Cancer Vaccine ATP128;
NCIt synonyms : Z12-MultiE/TLR Agonist Domain ATP128;
NCIt definition : A self-adjuvanted chimeric recombinant protein vaccine, based on the self-adjuvanting
KISIMA immunization platform, composed of three components: the 42 residue fragment
Z12, a cell penetrating peptide (CPP) derived from the ZEBRA protein transduction
domain, a toll-like receptor (TLR) peptide agonist as an adjuvant and a chimeric cargo,
a multiple antigenic domain (MAD; MultiE), that contains an as of yet not disclosed
amount of major histocompatibility class (MHC)-restricted peptides derived from as
of yet undisclosed tumor-associated antigens (TAAs) that are specific for colorectal
cancer (CRC) patients, with potential immunomodulating and antineoplastic activities.
Upon administration of ATP128, the Z12 moiety targets, binds to and penetrates antigen-presenting
cells (APCs), specifically dendritic cells (DCs) and promotes the loading of the epitopes
into the DCs and transports antigenic cargoes into both endosomal and cytosolic compartments.
Upon processing and antigen presentation by MHC II and I, the immune system is stimulated
and activates specific CD4 and CD8 T-cells, respectively, against the multi-epitopes
specific for the CRC cells, thereby killing the CRC cells.;
Molecule name : ATP-128; ATP 128;
NCI Metathesaurus CUI : CL978804;
Origin ID : C165621;
UMLS CUI : C5237317;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
