Preferred Label : Glutaminase-1 Inhibitor IACS-6274;
NCIt synonyms : GLS1 Inhibitor IACS-6274;
NCIt related terms : IPN-60090;
NCIt definition : An orally bioavailable inhibitor of the metabolic enzyme glutaminase-1 (GLS1), with
potential antineoplastic and immunostimulating activities. Upon oral administration,
IACS-6274 selectively targets, binds to and inhibits human GLS1, an enzyme that is
essential for the conversion of the amino acid glutamine into glutamate. Blocking
glutamine metabolism inhibits proliferation in rapidly growing tumor cells and leads
to an induction of cell death. Unlike normal healthy cells, glutamine-dependent tumors
heavily rely on the intracellular conversion of exogenous glutamine into glutamate
and glutamate metabolites to provide energy and generate building blocks for the production
of macromolecules, which are needed for cellular growth and survival.;
UNII : O6ZT4D087I;
CAS number : 1874231-60-3;
Molecule name : IPN 60090; IPN-60090; IACS 6274; IACS-6274;
NCI Metathesaurus CUI : CL978797;
Origin ID : C165612;
UMLS CUI : C5554571;
Semantic type(s)
- concept_is_in_subset
- has_target
