Preferred Label : Anti-CD205 Antibody-drug Conjugate OBT076;
NCIt synonyms : Anti-CD205 ADC OBT076;
NCIt definition : An antibody-drug conjugate (ADC) comprised of an anti-CD205 (lymphocyte antigen 75;
Ly75) humanized immunoglobin G1 (IgG1) monoclonal antibody conjugated to DM4, a maytansinoid
microtubule disruptor, via a cleavable N-succinimidyl-4-(2-pyridyldithio) butanoate
(SPDB) linker, with potential antineoplastic activity. Upon intravenous administration,
anti-CD205 ADC OBT076 specifically targets and binds to CD205, a receptor involved
in antigen capture and endocytosis, expressed on tumor cells. Following rapid internalization
of the ADC/CD205 complex, OBT076 releases its DM4 payload due to cleavage of the SPDB
linker by intracellular proteases. Then the DM4 binds to tubulin and disrupts microtubule
assembly/disassembly dynamics, resulting in the inhibition of both cell division and
cell growth of CD205-expressing tumor cells. CD205, a type I transmembrane surface
glycoprotein belonging to the C-type lectin receptor family, is normally expressed
on various antigen-presenting cells (APCs) and some leukocyte sub-populations but
it is overexpressed in multiple cancer types where it plays a key role in facilitating
metastatic invasion.;
Molecule name : MEN 1309; OBT-076; MEN-1309; OBT 076;
NCI Metathesaurus CUI : CL978811;
Origin ID : C165598;
UMLS CUI : C5237297;
Semantic type(s)
- concept_is_in_subset
- has_target
