NCIt definition : A half-life extended (HLE), human bispecific T-cell engager (BiTE) antibody composed
of two single-chain variable fragments (scFv), one directed against the tumor-associated
antigen (TAA) human mucin 17 (MUC17), and one directed against human CD3, a T-cell
surface antigen found on T-lymphocytes, with potential antineoplastic activity. Upon
administration vepsitamab binds to both CD3 on T-cells and MUC17 expressed on tumor
cells. This results in the cross-linking of T-cells and tumor cells, and induces a
potent cytotoxic T-lymphocyte (CTL) response against MUC17-expressing tumor cells.
MUC17, a member of the mucin family of glycoproteins, is overexpressed in a variety
of tumor cells of epithelial origin and plays a key role in tumor cell dissemination.;
Semantic type(s)