Preferred Label : STING Agonist SB 11285;
NCIt definition : An agonist of stimulator of interferon genes (STING) protein, with potential immunoactivating
and antineoplastic activities. Upon intravenous administration, STING agonist SB 11285
targets and binds to STING and activates the STING pathway, which promotes IKK-related
kinase TANK-binding kinase 1 (TBK1) signaling and activates nuclear factor-kappa B
(NF-kB) and interferon regulatory factor 3 (IRF3) in immune cells in the tumor microenvironment
(TME). This leads to the production of pro-inflammatory cytokines, including interferons
(IFNs). Specifically, expression of IFN-beta (IFNb) enhances the cross-presentation
of tumor-associated antigens (TAAs) by CD8alpha-positive and CD103-positive dendritic
cells (DCs) to cytotoxic T-lymphocytes (CTLs). This results in a CTL-mediated immune
response against tumor cells and causes tumor cell lysis.;
Molecule name : SB 11285; SB-11285;
NCI Metathesaurus CUI : CL978836;
Origin ID : C165566;
UMLS CUI : C5237275;
Semantic type(s)
- concept_is_in_subset
- has_target
