Preferred Label : Samarium Sm 153-DOTMP;
NCIt synonyms : Sm-153-1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetra(methylene)phosphonic Acid; Sm-153-DOTMP; Sm-153-1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayltetrakis(methylene)tetrakisphosphonic
Acid; 153Sm-DOTMP; 153 Sm-DOTMP;
NCIt related terms : DOTMP SM-153;
NCIt definition : A radioconjugate composed of the phosphonic acid chelator DOTMP (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylenephosphonic
acid) conjugated to the beta- and gamma-emitting radioisotope samarium Sm 153, with
potential antineoplastic activity. Upon administration of samarium Sm 153-DOTMP, the
DOTMP moiety targets and binds to growing bone, thereby selectively delivering samarium
Sm 153-mediated cytotoxic radiation to bone tumor and metastases, which may help destroy
bone metastases and mitigate pain from bone metastases.;
UNII : S5NN2E9ZKF;
CAS number : 633308-21-1;
Drug name : CycloSam;
NCI Metathesaurus CUI : CL978665;
Origin ID : C165558;
UMLS CUI : C5237267;
Semantic type(s)
- concept_is_in_subset
