Preferred Label : Alkotinib;
NCIt definition : An orally available inhibitor of multiple kinases, including the receptor tyrosine
kinase anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1), with potential
antineoplastic activity. Upon oral administration, alkotinib binds to and inhibits
the wild-type, point mutations and fusion proteins of ALK and ROS1. Inhibition of
these kinases leads to the disruption of downstream signaling pathways and the inhibition
of proliferation in tumor cells which these kinases are overexpressed, rearranged
or mutated.;
Molecule name : ZG 0418; ZG-0418;
NCI Metathesaurus CUI : CL978663;
Origin ID : C165556;
UMLS CUI : C5237265;
Semantic type(s)
- concept_is_in_subset
