Preferred Label : Anti-CD19 CAR T-cells XLCART001;
NCIt synonyms : CD19-specific CAR T-cells XLCART001;
NCIt definition : A preparation of T-lymphocytes that have been genetically modified to express a chimeric
antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing,
as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating
and antineoplastic activities. Upon administration, anti-CD19 CAR T-cells XLCART001
targets and binds to CD19-expressing tumor cells, thereby inducing selective toxicity
in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen
expressed in all B-cell lineage malignancies.;
Molecule name : XLCART001;
NCI Metathesaurus CUI : CL978681;
Origin ID : C165551;
UMLS CUI : C5237260;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
