Preferred Label : Oncolytic Newcastle Disease Virus MEDI5395;
NCIt synonyms : Oncolytic NDV MEDI5395; recNDV(GM-CSF); Recombinant NDV Expressing GM-CSF;
NCIt definition : An oncolytic viral agent containing the oncolytic, live-attenuated, replication-competent
strain of the avian paramyxovirus Newcastle disease virus (NDV) that has been engineered
to include a transgene encoding granulocyte-macrophage colony-stimulating factor (GM-CSF),
with potential antineoplastic and immunostimulating activities. Upon administration,
MEDI5395 specifically infects and replicates in cancer cells. This may result in a
direct cytotoxic effect involving the lysis of tumor cells via apoptotic mechanisms
and may eventually lead to an inhibition of cancer cell proliferation through the
increased production and secretion of pro-inflammatory cytokines and chemokines which
are able to recruit mediators of both the innate and adaptive immune responses. Additionally,
the inclusion of the GM-CSF transgene in the viral construct leads to expression of
GM-CSF, which may potentiate and strengthen the anti-tumor immune response.;
Molecule name : MEDI-5395; MEDI 5395;
NCI Metathesaurus CUI : CL978581;
Origin ID : C165457;
UMLS CUI : C5237198;
Semantic type(s)
- Virus [UMLS semantic type]
- concept_is_in_subset
