Preferred Label : Emzadirib;
NCIt synonyms : RAD51 Inhibitor CYT-0851;
NCIt definition : An orally bioavailable inhibitor of the DNA damage repair protein RAD51, with potential
antineoplastic and sensitizing activities. Upon oral administration, emzadirib targets,
binds to and inhibits the activity of RAD51. This prevents RAD51-mediated DNA damage
repair in susceptible tumor cells and induces tumor cell apoptosis. RAD51, the central
protein involved in homologous repair (HR) of DNA double-strand breaks (DSBs), is
overexpressed in many tumor cell types.;
UNII : B7AM3X83ZO;
CAS number : 2301085-04-9;
Molecule name : CYT 0851; CYT-0851;
NCI Metathesaurus CUI : CL978621;
Origin ID : C165436;
UMLS CUI : C5854845;
Semantic type(s)
- concept_is_in_subset
- has_target
