Preferred Label : PI3K-delta Inhibitor SHC014748M;
NCIt synonyms : PI3Kd Inhibitor SHC014748M;
NCIt definition : An orally available selective inhibitor of the delta isoform of phosphatidylinositol
3-kinase (PI3-kinase subunit delta; PI3K-delta; PI3Kdelta), with potential antineoplastic
activity. Upon oral administration, PI3K delta inhibitor SHC014748M selectively binds
to and inhibits PI3K delta and prevents the activation of the PI3K/AKT signaling pathway.
This decreases proliferation of and induces cell death in PI3K delta over-expressing
tumor cells. PI3K delta also plays a key role in the B-cell receptor (BCR) signaling
pathway and the proliferation of certain hematologic cancer cells. The targeted inhibition
of PI3K delta is designed to preserve PI3K signaling in normal, non-neoplastic cells,
thereby minimizing serious side effects.;
Molecule name : SHC 014748M; SHC-014748M;
NCI Metathesaurus CUI : CL978533;
Origin ID : C165266;
UMLS CUI : C5237038;
Semantic type(s)
- concept_is_in_subset
- has_target
