Preferred Label : Docetaxel Polymeric Micelles;
NCIt synonyms : Docetaxel-loaded PM; Docetaxel-loaded Polymeric Micelles; Docetaxel Lipid Emulsion; Docetaxel-loaded PMs; Docetaxel-PM;
NCIt definition : A nanoparticle-based formulation consisting of polymeric micelles (PMs), made with
poly(N-vinylpyrrolidone)-block-poly(D,L-lactide) (PVP-b-PDLLA) block polymers, encapsulating
the taxane docetaxel, a semi-synthetic analogue of paclitaxel, with potential antineoplastic
activity. Upon intravenous administration of the docetaxel PMs, the nanoparticles
are able to accumulate at the tumor site due to the unique characteristics of the
tumor's vasculature, while avoiding normal, healthy tissue. In turn, docetaxel is
released locally at the target tumor site where it binds specifically to the beta-tubulin
subunit of the microtubule, thereby stabilizing tubulin and inhibiting microtubule
disassembly. This results in cell-cycle arrest at the G2/M phase, thereby preventing
cell proliferation. This agent also inhibits pro-angiogenic factors such as vascular
endothelial growth factor (VEGF) and induces various mediators of the inflammatory
response. Compared to docetaxel alone, this formulation may enhance stability and
improve delivery, thereby increasing docetaxel's efficacy while avoiding systemic
exposure, which minimizes its toxicity.;
Drug name : NANOXEL-M;
NCI Metathesaurus CUI : CL978531;
Origin ID : C165263;
UMLS CUI : C5237036;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
