Preferred Label : Antigen-presenting Cells-expressing HPV16 E6/E7 SQZ-PBMC-HPV;
NCIt synonyms : APCs Expressing HPV16 E6/E7 SQZ-PBMC-HPV;
NCIt definition : A preparation of antigen presenting cells (APCs) specific for human papillomavirus
(HPV) type 16 E6 and E7 proteins, with potential immunomodulating and antineoplastic
activities. Autologous peripheral blood mononuclear cells (PBMCs) were ex vivo manipulated,
using a technique involving membrane disruption to get the HPV16 E6 and E7 proteins
into the cells; the resulting APCs present the antigens in a major histocompatibility
type I (MHC-I) manner. Upon administration of the APCs-expressing HPV16 E6/E7 SQZ-PBMC-HPV,
these cells activate the immune system to mount a cytotoxic T-lymphocyte (CTL) immune
response against tumor cells expressing HPV16 E6 and E7. HPV16 E6 and E7 play an important
role in the development of certain types of cancer.;
Molecule name : SQZ-PBMC-HPV; SQZ PBMC HPV;
NCI Metathesaurus CUI : CL978557;
Origin ID : C165256;
UMLS CUI : C5237032;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
