Preferred Label : Flaxseed Lignan;
NCIt synonyms : Flax Lignan;
NCIt definition : A group of bioactive polyphenolic phytoestrogens derived from the seed of the flax
plant (Linum usitatissimum) with potential antioxidant and chemopreventive activities.
Flaxseed lignan is primarily comprised of secoisolariciresinol diglucoside (SDG),
isolariciresinol, matairesinol, pinoresinol and lariciresinol. SDG is converted to
the enterolignans enterolactone (EL) and enterodiol (ED) by the intestinal microflora
in the proximal colon. EL and ED have both weakly estrogenic and anti-estrogenic activities
depending upon the tissue. The anti-estrogenic effects in reproductive tissue may
help reduce the risk of hormone-associated cancers, while the estrogenic effects in
bone may help maintain bone density. Flaxseed is the richest dietary source of lignans.;
NCI Metathesaurus CUI : CL978415;
Origin ID : C165203;
UMLS CUI : C5236981;
Semantic type(s)
concept_is_in_subset