Motexafin Lutetium

Preferred Label : Motexafin Lutetium;

NCIt synonyms : Lu-Tex; Lutetium Texaphrin; Lutetium Texaphyrin;

NCIt related terms : Lu tex; Lutex;

NCIt definition : A pentadentate aromatic metallotexaphyrin with photosensitizing properties. Motexafin lutetium preferentially accumulates in tumor cells due to their increased rates of metabolism and absorbs light, forming an extended high energy conformational state that produces high quantum yields of singlet oxygen, resulting in local cytotoxic effects. (NCI04);

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer using photodynamic therapy. It belongs to the family of drugs called metallotexaphyrins.;

UNII : 0A85BJ22L6;

InChIKey : WIQKYZYFTAEWBF-IOYKFIIZSA-L;

CAS number : 246252-04-0; 156436-90-7;

Drug name : Antrin; Lutex; Lutrin; Optrin;

Molecule name : PCI-0123;

Chemical formula : C48H66N5O10.2C2H3O2.Lu.H2O;

NSC code : 695239;

Codes from synonyms : NSC0695239; CDR0000045469; CDR0000390301; NSC0009704;

Details

Origin ID

C1651;

UMLS CUI

C0338310;

Automatic exact mappings (from CISMeF team)
- Lu-Tex [MeSH concept]
- wrestling [MeSH Descriptor]
Currated CISMeF NLP mapping
- motexafin lutetium [MeSH concept]
- motexafin lutetium [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- motexafin lutetium [MeSH concept]
- motexafin lutetium [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Free Radical Formation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- DNA Double Strand Break [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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