Peldesine - CISMeF

Preferred Label : Peldesine;

NCIt synonyms : Peldesina; 9-(3-Pyridinylmethyl)-7H-9-deazaguanine; 4H-Pyrrolo(3,2-d)pyrimidin-4-one,1,5-dihydro-2-amino-7-(3-pyridinylmethyl);

NCIt definition : A pyrimidine analogue and purine nucleoside phosphorylase inhibitor with immunosuppressive and antineoplastic properties. Peldesine inhibits purine nucleoside phosphorylase (PNP) that plays a pivotal role in T-cell proliferation and is responsible for the catalysis of the reversible phosphorolytic cleavage of purine ribonucleosides and 2'-deoxyribonucleosides. Inhibition of PNP results in accumulation of dGTP and the subsequent failure of DNA synthesis. This agent maybe used in T-cell related autoimmune diseases including psoriasis, rheumatoid arthritis and Crohn s disease and T-cell cancers;

Alternative definition : NCI-GLOSS: A substance that is being studied for the treatment of cancer.;

UNII : 7B646RJ70F;

InChIKey : DOHVAKFYAHLCJP-UHFFFAOYSA-N;

CAS number : 133432-71-0;

Molecule name : BCX-34;

Chemical formula : C12H11N5O;

Codes from synonyms : CDR0000045464;

Details

Origin ID

C1650;

UMLS CUI

C0338278;

Currated CISMeF NLP mapping
- peldesine [MeSH concept]
- peldesine [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- peldesine [MeSH concept]
- peldesine [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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