" /> Peldesine - CISMeF





Preferred Label : Peldesine;

NCIt synonyms : Peldesina; 9-(3-Pyridinylmethyl)-7H-9-deazaguanine; 4H-Pyrrolo(3,2-d)pyrimidin-4-one,1,5-dihydro-2-amino-7-(3-pyridinylmethyl);

NCIt definition : A pyrimidine analogue and purine nucleoside phosphorylase inhibitor with immunosuppressive and antineoplastic properties. Peldesine inhibits purine nucleoside phosphorylase (PNP) that plays a pivotal role in T-cell proliferation and is responsible for the catalysis of the reversible phosphorolytic cleavage of purine ribonucleosides and 2'-deoxyribonucleosides. Inhibition of PNP results in accumulation of dGTP and the subsequent failure of DNA synthesis. This agent maybe used in T-cell related autoimmune diseases including psoriasis, rheumatoid arthritis and Crohn s disease and T-cell cancers;

Alternative definition : NCI-GLOSS: A substance that is being studied for the treatment of cancer.;

UNII : 7B646RJ70F;

InChIKey : DOHVAKFYAHLCJP-UHFFFAOYSA-N;

CAS number : 133432-71-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 133432-71-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : BCX-34;

Chemical formula : C12H11N5O;

Codes from synonyms : CDR0000045464;

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12/05/2024


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