Preferred Label : Performed Clinical Result Target Biomarker Code;
NCIt related terms : PerformedClinicalResult.targetBiomarkerCode;
Alternative definition : BRIDG 5.3: A coded value specifying a variation in cellular or biochemical components
or processes, structures, or functions that is objectively measurable in a biological
system and that characterizes normal biologic processes, pathogenic processes, an
organism's state of health or disease, likelihood of developing a disease, prognosis,
or response to a particular therapeutic intervention. This is the focus of an observation.
EXAMPLE(S): Biomarkers include but are not limited to such phenotypic parameters as
specific enzyme or hormone concentration, specific gene phenotype, presence or absence
of biological substance. For an observation with a nameCode of Determine the Allele
for the HLA-A Locus on Chromosome 6, the observation result might have a targetBiomarkerCode
of HLA-A and a value of HLA-A*01:01:01 (the specific allele) For an observation with
a nameCode of Determine the variant nucleotide for Single Nucleotide Polymorphism
RS110789, the observation result might have a targetBiomarkerCode of Rs110789 and
a value of C (cytosine, the specific nucleotide that is variant) OTHER NAME(S): Genetic
Marker NOTE(S): There is no associated 'approach' for a Biomarker, as there is for
an anatomic site. In the context of Bone Marrow Transplantation, the bodily substance
that is collected to determine the Biomarker (the HLA Alleles) is typically blood
or saliva. Thus, the thing that is collected is the typeCode of the Material that
is collected via a PerformedSpecimenCollection. The attribute 'targetBiomarkerCode'
was chosen as inclusive of 'targetGeneticMarkerCode', which is more specific to the
Bone Marrow Transplantation domain. However, the Life Sciences Domain Analysis Model
is using Biomarker as the focus of their Genomic Analysis, and thus this broader definition
was chosen to facilitate that alignment.;
NCI Metathesaurus CUI : CL978055;
Origin ID : C164915;
UMLS CUI : C5236709;
Semantic type(s)
- concept_is_in_subset
