NCIt definition : A T-cell engaging, human, bispecific, immunoglobulin G4 (IgG4) monoclonal antibody
(T-BsAb) directed against the tumor-associated antigen (TAA) human B-cell maturation
antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and
CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic
activities. Upon administration, etentamig binds to both CD3 on cytotoxic T-lymphocytes
(CTLs) and BCMA found on BCMA-expressing tumor cells. This activates and redirects
CTLs to BCMA-expressing tumor cells, which results in the CTL-mediated cell death
of BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis factor receptor
superfamily that is specifically overexpressed on malignant plasma cells, plays a
key role in promoting plasma cell survival. Binding to low-activating CD3 preferentially
activates effector over regulatory T-cells and stimulates minimum cytokine release.;
UNII : CO86AOP337;
CAS number : 2490552-52-6;
Molecule name : TNB-383B; TNB 383B; ABBV-383; ABBV 383;
Semantic type(s)