NCIt definition : A T-cell engaging, human, bispecific, immunoglobulin G4 (IgG4) monoclonal antibody
(T-BsAb) directed against the tumor-associated antigen (TAA) human B-cell maturation
antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and
CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic
activities. Upon administration, anti-BCMA/anti-CD3 T-cell engaging bispecific antibody
ABBV-383 binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and BCMA found on BCMA-expressing
tumor cells. This activates and redirects CTLs to BCMA-expressing tumor cells, which
results in the CTL-mediated cell death of BCMA-expressing tumor cells. BCMA, a member
of the tumor necrosis factor receptor superfamily that is specifically overexpressed
on malignant plasma cells, plays a key role in promoting plasma cell survival. Binding
to low-activating CD3 preferentially activates effector over regulatory T-cells and
stimulates minimum cytokine release.;
Molecule name : TNB-383B; TNB 383B; ABBV-383; ABBV 383;
Semantic type(s)