" /> Etentamig - CISMeF





Preferred Label : Etentamig;

NCIt synonyms : Anti-BCMA x aCD3 T-cell Engaging Bispecific Antibody TNB-383B; Anti-BCMA x aCD3 T-BsAb TNB-383B; Anti-alpha BCMA/Anti-alpha CD3 T-cell Engaging Bispecific Antibody TNB-383B; BCMA x CD3 T-cell Engaging Bispecific Antibody ABBV-383; Anti-BCMA/Anti-CD3 T-cell Engaging Bispecific Antibody ABBV-383;

NCIt definition : A T-cell engaging, human, bispecific, immunoglobulin G4 (IgG4) monoclonal antibody (T-BsAb) directed against the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, etentamig binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and BCMA found on BCMA-expressing tumor cells. This activates and redirects CTLs to BCMA-expressing tumor cells, which results in the CTL-mediated cell death of BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival. Binding to low-activating CD3 preferentially activates effector over regulatory T-cells and stimulates minimum cytokine release.;

UNII : CO86AOP337;

CAS number : 2490552-52-6;

Molecule name : TNB-383B; TNB 383B; ABBV-383; ABBV 383;

NCI Metathesaurus CUI : CL977826;

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08/05/2025


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