Preferred Label : Multi-mode Kinase Inhibitor EOC317;
NCIt synonyms : Urea, N-[4-[4-amino-6-(methoxymethyl)-7-(4-morpholinylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2-fluorophenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]-;
NCIt related terms : ACTB-1003;
NCIt definition : An orally available, small molecule, multi-mode kinase inhibitor (MMKI), with potential
antineoplastic activity. Upon oral administration, MMKI EOC317 targets, binds to and
inhibits the activity of a variety of kinases, such as phosphatidylinositol 3 kinase
(PI3K), and the receptor tyrosine kinases, fibroblast growth factor receptor (FGFR),
angiopoietin-1 receptor (TIE 2), and vascular endothelial growth factor receptor-2
(VEGFR-2). This inhibition may result in an induction of apoptosis of susceptible
tumors cells in which these kinases are overexpressed.;
UNII : 44750KD9OE;
CAS number : 939805-30-8;
Molecule name : ACTB-1003; EOC-317; EOC 317; ONC201MMKI EOC317; EDP317;
NCI Metathesaurus CUI : CL977499;
Origin ID : C164211;
UMLS CUI : C5236062;
Semantic type(s)
- concept_is_in_subset
