Preferred Label : iPSC-derived CD16-expressing Natural Killer Cells FT516;
NCIt synonyms : Induced Pluripotent Stem Cell-derived CD16-expressing NK Cells FT516; Induced Pluripotent Stem Cell-derived CD16-expressing Natural Killer Cells FT516;
NCIt related terms : FT-516;
NCIt definition : An allogeneic, off-the-shelf, natural killer (NK) cell product derived from a clonal
master induced pluripotent stem cell (iPSC) line, and engineered to express a high-affinity,
non-cleavable CD16 (hnCD16) Fc receptor, with potential antineoplastic and immunostimulatory
activities. Upon administration, iPSC-derived CD16-expressing NK cells FT516 bind
to the Fc portion of tumor cell-bound monoclonal antibodies and activate NK cell activation,
cytokine secretion and antibody-dependent cellular cytotoxicity (ADCC). CD16, also
known as Fc-gamma receptor III, is normally expressed on the surface of NK cells,
neutrophils, monocytes and macrophages, and plays a key role in initiating ADCC. It
is often downregulated in certain cancers, thereby inhibiting the anti-tumor immune
response. FT516 NK cells' hnCD16 Fc receptor prevents downregulation and optimizes
binding to tumor-targeting antibodies for enhanced ADCC.;
UNII : 3NBZ936ONT;
Molecule name : FT 516; FT-516;
NCI Metathesaurus CUI : CL977336;
Origin ID : C164140;
UMLS CUI : C5236007;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
