Preferred Label : Avotaciclib;
NCIt synonyms : CDK1 Inhibitor BEY1107;
NCIt definition : An orally bioavailable, cyclin dependent kinase 1 (CDK1) inhibitor, with potential
antineoplastic activity. Upon administration, avotaciclib targets, binds to and inhibits
the activity of CDK1. This may inhibit cancer stem cell (CSC) division, cause cell
cycle arrest, and induce apoptosis. This may inhibit tumor cell proliferation. CDK1,
an ATP-dependent serine/threonine kinase, plays a key role in regulating cell division,
cell cycle progression and proliferation. It is frequently overexpressed in tumor
cells.;
UNII : Z6BYC0F36E;
InChIKey : VFVAQKKPFOPZEA-UHFFFAOYSA-N;
CAS number : 1983983-41-0;
Molecule name : BEY1107G; BEY-1107; BEY-A; BEY1107P; BEY 1107;
NCI Metathesaurus CUI : CL977268;
Origin ID : C163985;
UMLS CUI : C5446349;
Semantic type(s)
- concept_is_in_subset
