NCIt definition : A glycoengineered humanized version of the monoclonal antibody of cetuximab, with
potential antineoplastic activity. Upon intravenous administration, pimurutamab selectively
targets and binds to the extracellular domain of the epidermal growth factor receptor
(EGFR), thereby preventing the activation and subsequent dimerization of the receptor.
This may prevent EGFR-mediated signaling and inhibit EGFR-dependent tumor cell proliferation.
In addition, the glyco-optimization promotes antibody-dependent cell-mediated cytotoxicity
(ADCC). EGFR, a member of the epidermal growth factor family of extracellular protein
ligands, may be overexpressed on the cell surfaces of certain tumor types.;
UNII : 5V1Y8T4RB6;
CAS number : 2251771-76-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2251771-76-1
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G-SRS /a ;
Semantic type(s)