Preferred Label : Fluorine F 18-AlF-cys-variant 3 pH Low Insertion Peptides;
NCIt synonyms : Fluorine F 18-cys-Var3 pHLIP; [18F]AlF-cysVar3 pHLIP; 18F-AlF-Var3 pHLIP;
NCIt definition : A radioconjugate composed of pH (low) insertion peptides (pHLIP) variant 3 (Var3)
conjugated, via a cysteine residue, to fluorine F 18-labeled aluminum fluoride (AlF)
complex, with potential use as an imaging agent for the acidic extracellular environment
surrounding tumors upon positron emission tomography (PET). Upon administration of
fluorine F 18-AlF-cys-Var3 pHLIP, the Var3 pHLIP moiety specifically targets, tightly
binds to and gets inserted into the cellular membrane of tumor cells in environments
with low extracellular pH. Upon PET, tumor cells and the extent of acidity can be
visualized and assessed using PET. Tumor cell environments are more acidic than normal,
healthy tissue environments. The pHLIPs specifically fold into an alpha-helical conformation
and become inserted across the membrane at low extracellular pH whereas they are unfolded
and unbound at higher pHs.;
NCI Metathesaurus CUI : CL976969;
Origin ID : C163807;
UMLS CUI : C5235700;
Semantic type(s)
- concept_is_in_subset
