Preferred Label : Targeted Therapy Agent;
NCIt synonyms : Targeted Agent; Anti-tumor Targeted Therapy Agent; Molecularly Targeted Therapy Agent; Targeted Therapeutic Agent;
NCIt definition : Any agent that specifically targets or interferes with the synthesis or function of
a molecule that is expressed specifically in or on cells of the tumor and/or the tumor
microenvironment (TME), such as immune cells or surrounding blood vessels. The targeted
molecule is usually overexpressed or mutated in tumors but minimally or not expressed
by normal, healthy tissues; additionally, expression is typically associated with
tumor cell proliferation, progression and/or survival. By blocking the function or
expression of the tumor-associated target, the targeted therapy agent may exert potential
antineoplastic and/or immunomodulatory activities.;
NCIt note : Includes mainly antibodies, small molecules and antibody-drug conjugates (ADCs). As
of September 2019, this therapy agent tree does not include immune cells, such as
CAR-T cells, vaccines, gene therapy agents and radio(immuno)conjugates. Targets featured
in this tree are the most common targets against which agents are being developed
or have been approved. New target/agent categories in this tree will be identified
and added based on user needs and new drug developments.;
NCI Metathesaurus CUI : CL976985;
Origin ID : C163758;
UMLS CUI : C5235658;
Semantic type(s)
- concept_is_in_subset
