Preferred Label : EGF Vaccine EGF-PTI;
NCIt synonyms : EGF Pathway-targeted Immunotherapeutic; EGF Pathway Targeted Immunotherapy Agent; EGF-TPI; EGF Pathway Targeted Immunization Agent;
NCIt definition : A cancer vaccine containing epidermal growth factor (EGF), with immunomodulating and
antineoplastic activities. Upon administration of the EGF vaccine EGF-PTI, EGF induces
an immune response against EGFR, which results in the formation of anti-EGF-specific
neutralizing antibodies. This causes binding of the anti-EGF antibodies to endogenous
EGF, reduces levels of circulating EGF and prevents the binding of EGF to its receptor
EGFR. This prevents EGF/EGFR pathway activation and may result in an inhibition of
proliferation in EGFR-overexpressing tumor cells. EGF/EGFR-mediated signaling is overactivated
in certain cancer types and drives tumor cell proliferation and progression.;
NCI Metathesaurus CUI : CL973373;
Origin ID : C163023;
UMLS CUI : C5206893;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
