Preferred Label : Recombinant Interleukin-14;
NCIt synonyms : Interleukin 14; High Molecular Weight-B-Cell Growth Factor; IL-14; HMW-BCGF; Therapeutic Interleukin-14;
NCIt definition : A recombinant peptide, which is chemically identical or similar to the endogenous
cytokine interleukin-14 (IL-14). The cytokine inhibits immunoglobulin secretion and
selectively expands activated B-cell subpopulations. An IL-14 receptor is found on
activated B-cells, but not in resting B-cells. This agent is unrelated to other cytokines
but has homology with complement factor Bb. Autocrine or paracrine production of IL-14
may play a significant role in the rapid proliferation of aggressive non-Hodgkin lymphoma
(NHL-B). Interrupting this pathway could be a useful goal of therapy for patients
resistant to conventional chemotherapy.;
Origin ID : C1630;
UMLS CUI : C1522568;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- chemical_or_drug_has_physiologic_effect
