Plevitrexed - CISMeF

Preferred Label : Plevitrexed;

NCIt synonyms : Vamidex; Vamydex; (alphaS)-alpha-[[4-[[(1,4-Dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-2-fluorobenzoyl]amino]-1H-tetrazole-5-butanoic Acid;

NCIt definition : An orally bioavailable, small molecule, non-polyglutamatable, antifolate quinazoline derivative thymidine synthetase inhibitor with potential antineoplastic activity. Plevitrexed is transported into the cell via the physiological reduced folate carrier (RFC) system. Intracellularly, this agent selectively binds to the folate binding site of thymidylate synthase and inhibits thymidine synthesis, which may result in DNA synthesis inhibition and apoptosis.;

UNII : L9P2881C3H;

InChIKey : IEJSCSAMMLUINT-NRFANRHFSA-N;

CAS number : 153537-73-6;

Molecule name : ZD9331; BGC 9331;

Chemical formula : C26H25FN8O4;

Codes from synonyms : 50641;

Details

Origin ID

C1629;

UMLS CUI

C1948069;

Automatic exact mappings (from CISMeF team)
- ZD 9331 [MeSH concept]
- ZD 9331 [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- Plevitrexed (substance) [SNOMED CT concept]
- Product containing plevitrexed (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Plevitrexed (substance) [SNOMED CT concept]
- Product containing plevitrexed (medicinal product) [SNOMED CT concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Topotecan/ZD9331 [NCIt concept]

Keyword's position in hierarchy(ies) :

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