" /> Plevitrexed - CISMeF





Preferred Label : Plevitrexed;

NCIt synonyms : Vamidex; Vamydex; (alphaS)-alpha-[[4-[[(1,4-Dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-2-fluorobenzoyl]amino]-1H-tetrazole-5-butanoic Acid;

NCIt definition : An orally bioavailable, small molecule, non-polyglutamatable, antifolate quinazoline derivative thymidine synthetase inhibitor with potential antineoplastic activity. Plevitrexed is transported into the cell via the physiological reduced folate carrier (RFC) system. Intracellularly, this agent selectively binds to the folate binding site of thymidylate synthase and inhibits thymidine synthesis, which may result in DNA synthesis inhibition and apoptosis.;

UNII : L9P2881C3H;

InChIKey : IEJSCSAMMLUINT-NRFANRHFSA-N;

CAS number : 153537-73-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 153537-73-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : ZD9331; BGC 9331;

Chemical formula : C26H25FN8O4;

Codes from synonyms : 50641;

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Keyword's position in hierarchy(ies) : arborescence

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12/05/2024


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