Preferred Label : Rusfertide;
NCIt synonyms : Hepcidin Agonist PTG-300; Hepcidin Mimetic PTG-300;
NCIt definition : An injectable peptide mimetic of hepcidin (hepcidin antimicrobial peptide; HAMP; putative
liver tumor regressor; PLTR; liver-expressed antimicrobial peptide 1; LEAP-1) with
potential use in the treatment of iron deficiency anemia and iron overload secondary
to hematologic disorders. Upon administration, rusfertide mimics endogenous hepcidin,
a protein primarily produced in hepatocytes, and increases hepcidin levels. As hepcidin
plays a key role in the homeostasis of systemic iron, rusfertide may serve to normalize
iron levels. Low levels of endogenous hepcidin are associated with iron overload secondary
to excessive absorption of iron as seen in beta thalassemia and paradoxically with
iron deficiency anemia.;
UNII : XM71MYX0IQ;
CAS number : 1628323-80-7;
Molecule name : PTG 300; PTG-300;
NCI Metathesaurus CUI : CL973321;
Origin ID : C162883;
UMLS CUI : C5554569;
Semantic type(s)
- concept_is_in_subset
