Preferred Label : Lignin-derived Polyphenolic Composition with Ammonium Molybdate BP-C2;
NCIt synonyms : Molybdenum Salts of Benzene-polycarboxylic Acids BP-C2; Benzene-poly-carboxylic Acid Complex with Molybdenum BP-C2;
NCIt definition : An orally bioavailable solution containing lignin-derived benzene-polycarboxylic acids
mixed with ammonium molybdate, with potential use as an adjuvant and with potential
radioprotective and regenerative activities. Upon oral administration, lignin-derived
polyphenolic composition with ammonium molybdate BP-C2 is also able to stimulate the
innate immune system and upregulates a variety of cytokines including interferon (IFN),
tumor necrosis factor-alpha (TNF-alpha), granulocyte macrophage-colony stimulating
factor (GM-CSF), and various interleukins (ILs) such as IL-6, IL-22 and IL-25, and
induces the production of innate lymphoid cells. BP-C2 stimulates the production of
intestinal epithelial cells thereby protecting the gastrointestinal (GI) tract against
GI-induced cytotoxic side effects caused by certain anti-tumor agents. Additionally,
BP-C2 scavenges free radicals, inhibits lipid oxidation, and protects cells against
radiation-induced damage. Molybdenum, an essential micronutrient, acts as a cofactor
in multiple detoxification system enzymes. BP-C2 may also stimulate the production
of hematopoietic progenitor cells, thereby correcting hematological abnormalities
such as anemia, thrombocytopenia and neutropenia, which are also caused by certain
anti-cancer agents.;
Molecule name : BP-C2; BP C2;
NCI Metathesaurus CUI : CL973358;
Origin ID : C162877;
UMLS CUI : C5206855;
Semantic type(s)
- concept_is_in_subset
