Preferred Label : Neoantigen Vaccine GEN-009;
NCIt synonyms : GEN-009 Vaccine; Personalized Cancer Vaccine GEN-009;
NCIt definition : A peptide-based, personalized cancer vaccine consisting of patient-specific mutated
synthetic long peptides (SLPs), which are immunogenic and unique to the patient's
tumor, with potential immunomodulating and antineoplastic activities. Upon subcutaneous
vaccination with the personalized neoantigen peptide vaccine GEN-009, and administration
along with the immunoadjuvant poly-ICLC, the peptides stimulate the host immune system
to mount a specific and potent cytotoxic T-lymphocyte (CTL) response against tumor
cells expressing the neoantigens, which results in tumor cell lysis. The Antigen Lead
Acquisition System (ATLAS) will be used to identify neoantigens in each patient's
tumor that are recognized by their CD4 and/or CD8 T-cells and will be incorporated
into GEN-009 in the form of SLPs. Each personalized vaccine contains between four
and twenty SLPs.;
Molecule name : GEN 009; GEN-009;
NCI Metathesaurus CUI : CL973355;
Origin ID : C162874;
UMLS CUI : C5206852;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
