Preferred Label : Anti-VEGF/TGF-beta 1 Fusion Protein HB-002T;
NCIt definition : A recombinant, human immunoglobulin Fc fusion protein targeting both the transforming
growth factor (TGF) beta 1 (TGF-beta 1; TGFb1) and the vascular endothelial growth
factor (VEGF), with potential anti-angiogenic and antineoplastic activities. Upon
administration of anti-VEGF/TGF-beta 1 fusion protein HB-002T, the fusion protein
specifically and selectively targets, binds to and neutralizes both TGF-beta 1 and
VEGF. This prevents TGFb1- and VEGF-mediated signaling and abrogates VEGF/VEGFR-induced
angiogenesis and TGFb1-mediated induction of VEGF, which further inhibits angiogenesis.
It also inhibits TGFb1-mediated immunosuppression, thereby enhancing anti-tumor immunity
in the tumor microenvironment (TME) and promoting a cytotoxic T-lymphocyte (CTL)-mediated
immune response against tumor cells leading to tumor cell death.;
Molecule name : HB-002T; HB002.1T; HB 002T;
NCI Metathesaurus CUI : CL973357;
Origin ID : C162872;
UMLS CUI : C5206850;
Semantic type(s)
- concept_is_in_subset
