Preferred Label : Adenoviral Tumor-specific Neoantigen Priming Vaccine GAd-209-FSP;
NCIt synonyms : Great Ape Adenoviral Tumor-specific Neoantigen Priming Vaccine GAd-209-FSP;
NCIt definition : An off-the-shelf neoantigen priming vaccine comprised of a great ape adenovirus (GAd)
encoding tumor-specific neoantigens (TSNAs) derived from as of yet undisclosed frameshift
peptides (FSPs) with potential immunostimulatory and antineoplastic activities. Upon
intramuscular administration of the adenoviral tumor-specific neoantigen priming vaccine
GAd-209-FSP, the adenovirus infects cells and expresses the TSNAs. This stimulates
the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor
cells expressing the TSNAs, leading to tumor cell lysis. Adenoviral-TSNA priming vaccine
GAd-209-FSP is followed by boosting with a vaccine that encodes the same target TSNAs.;
Molecule name : GAd-209-FSP; GAd20-209-FSP;
NCI Metathesaurus CUI : CL973183;
Origin ID : C162805;
UMLS CUI : C5206828;
Semantic type(s)
- concept_is_in_subset
