Preferred Label : Docetaxel/Ritonavir;
NCIt synonyms : Oral Docetaxel/Ritonavir;
NCIt definition : An orally bioavailable combination agent containing docetaxel, a second generation
taxane, and ritonavir, a cytochrome P450 (CYP) 3A4 inhibitor, with potential enhanced
antineoplastic activity. Docetaxel binds to and stabilizes tubulin, thereby inhibiting
microtubule disassembly which results in cell-cycle arrest at the G2/M phase and cell
death. Docetaxel is metabolized by CYP3A4 enzymes which is inhibited by the presence
of ritonavir. This increases the plasma concentration of docetaxel and may increase
docetaxel's efficacy.;
Drug name : ModraDoc006/r;
NCI Metathesaurus CUI : CL973164;
Origin ID : C162784;
UMLS CUI : C5206821;
Semantic type(s)
- concept_is_in_subset
- has_target
