Preferred Label : Anti-CD70 CAR-expressing T Lymphocytes;
NCIt synonyms : Anti-CD70 CAR-expressing T-cells; CD70 CAR T-cells; CD70 CAR T-lymphocytes;
NCIt definition : A preparation of human T-lymphocytes transduced with a recombinant viral vector encoding
a chimeric T-cell receptor (chimeric antigen receptor or CAR) consisting of one or
more binding domains that target the tumor-associated antigen (TAA) CD70 (CD27 ligand;
tumor necrosis factor superfamily member 7; TNFSF7) fused to one or more co-stimulatory
TCR-signaling domains, with potential immunostimulating and antineoplastic activities.
Upon administration, the anti-CD70 CAR-expressing T-lymphocytes, express anti-CD70-CAR
on their cell surfaces and bind to the CD70 antigen on tumor cell surfaces thereby
neutralizing the activity of CD70. This may induce antibody-dependent cellular cytotoxicity
(ADCC) against CD70-expressing tumor cells. CD70, a cytokine belonging to the tumor
necrosis superfamily (TNFSF) and the ligand for the costimulatory receptor CD27, is
expressed on the surfaces of various types of cancer cells; its overexpression may
play an important role in the evasion of immune surveillance.;
NCI Metathesaurus CUI : CL973102;
Origin ID : C162699;
UMLS CUI : C5206754;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
