NCIt definition : A fully human monoclonal antibody directed against the cell surface receptor CD39
(cluster of differentiation 39; ectonucleoside triphosphate diphosphohydrolase-1;
NTPDase1; ENTPD1) with potential immunomodulating and antineoplastic activities. Upon
administration, eltivutabart specifically binds to the CD39 antigen, which may inhibit
both the conversion of adenosine triphosphate (ATP) to adenosine monophosphate (AMP)
and the subsequent generation of immunosuppressive extracellular adenosine in the
tumor microenvironment (TME). CD39, a cell surface ectonucleosidase, is upregulated
on tumor cells as an immune evasion strategy; blocking its action may promote the
stimulation of dendritic and other myeloid-derived cells that are necessary for both
innate and adaptive immunity.;
Semantic type(s)