Preferred Label : Indium In 111-Autologous CMV-pp65-LAMP mRNA Loaded Dendritic Cells;
NCIt synonyms : 111In-labeled pp65-LAMP mRNA Loaded Mature Autologous DCs; Indium In 111-CMV pp65-LAMP mRNA-pulsed Autologous DCs; Indium In 111-labeled CMV pp65 Peptide-pulsed Autologous DCs; 111In-labeled Autologous CMV-pp65-LAMP mRNA Loaded Dendritic Cells;
NCIt definition : A radioimmunoconjugate composed of mature autologous dendritic cells (DCs) generated
from peripheral blood leukocytes pulsed with mRNA encoding for a fusion protein comprised
of the human cytomegalovirus (CMV) matrix protein pp65 (65 kDa lower matrix phosphoprotein;
UL83) fused with the lysosome-associated membrane protein (pp65-LAMP) and radiolabeled
with the isotope indium In 111, with potential ability to track DC migration upon
single-photon emission computed tomography (SPECT)/ computed tomography (CT). Upon
intradermal injection of the indium In 111-autologous CMV pp65-LAMP mRNA loaded DCs
into the groin area, the DCs migrate in vivo to the inguinal lymph nodes. Upon SPECT/CT
imaging, DC in vivo migration to the lymph nodes can be assessed.;
NCI Metathesaurus CUI : CL971035;
Origin ID : C162641;
UMLS CUI : C5206714;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
