Preferred Label : Chimeric Costimulatory Converting Receptor-modified NK-92 Cells;
NCIt synonyms : Chimeric Co-stimulatory Converting Receptor-modified NK92 Cells; CCCR-modified NK92 Cells; CCCR-NK92 Cells;
NCIt definition : A preparation of genetically-modified natural killer (NK) cells derived from the allogeneic
NK-92 cell line that are transduced with an as of yet unspecified chimeric costimulatory
converting receptor (CCCR) for cancer retargeting purposes, with potential cytolytic,
immunomodulating and antineoplastic activities. Upon infusion of the CCCR-modified
NK-92 cells, the redirected NK cells recognize and bind to tumor cells. This leads
to the secretion and release of perforins, granzymes, cytokines and chemokines, which
results in selective tumor cell lysis. The NK-92 cells are derived from a human cytotoxic
cell line composed of allogeneic, activated, interleukin-2-(IL-2) dependent-NK cells
from a 50-year old male patient with rapidly progressive non-Hodgkin's lymphoma. As
NK-92 cells are devoid of killer inhibitory receptors (KIRs; also called killer cell
immunoglobulin-like receptors), which are negative regulators of NK cell activity,
cancer cells are unable to suppress the cancer cell killing ability of the NK-92 cells.;
NCI Metathesaurus CUI : CL971025;
Origin ID : C162637;
UMLS CUI : C5206711;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
