Preferred Label : Adenoviral Vector Encoding VEGF-C LX-1101;
NCIt synonyms : VEGFC-expressing Gene Therapeutic LX-1101; AdAptVEGF-C Adenoviral Vector LX-1101;
NCIt definition : A genetically engineered, replication-deficient adenovirus carrying the gene encoding
for the human vascular endothelial growth factor C (VEGFC; VEGF-C; Flt4 ligand), with
potential pro-angiogenic activity. Upon perinodal administration of the AdAptVEGF-C
adenoviral vector LX-1101, the adenovirus infects cells and promotes expression of
VEGF-C. In turn, VEGF-C induces vascular and lymphatic endothelial cell proliferation
locally, and may help re-grow the lymphatic system and improve symptoms associated
with lymphedema (LE). VEGF-C, a lymphatic growth factor, plays a key role in (lymph)angiogenesis
and the functioning of the lymphatic system.;
Drug name : Lymfactin;
Molecule name : LX 1101; LX-1101;
NCI Metathesaurus CUI : CL971028;
Origin ID : C162634;
UMLS CUI : C5206708;
Semantic type(s)
- concept_is_in_subset
