Preferred Label : Sacubitril/Valsartan;
NCIt synonyms : Sacubitril Mixture With Valsartan; 3-(1-Biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-3'-methyl-2'-(pentanoyl(2'-(tetrazol-5-ylate)biphenyl-4'-ylmethyl)amino)butyrate; Sacubitril/Valsartan Sodium Hydrate; Sacubitril-Valsartan; L-Valine, N-(1-oxopentyl)-N-((2'-(2H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-,
compd. with alpha-ethyl(alphaR,gammaS)-gamma-((3-carboxy-1-oxopropyl)amino)-alpha-methyl(1,1'-biphenyl)-4-pentanoate,
sodium salt, hydrate (2:2:6:5); Trisodium (3-(1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-3'-methyl-2'-(pentanoyl(2'-(tetrazol-5-ylate)biphenyl-4'-ylmethyl)amino)butyrate)
hemipentahydrate; LCZ-696;
NCIt related terms : SACUBITRIL VALSARTAN SODIUM HYDRATE; Entresto;
NCIt definition : A combination of sacubitril and valsartan with natriuretic and anti-hypertensive properties.
Upon administration, sacubitril is metabolized by esterases to its active metabolite,
LBQ657 (sacubitrilat), which inhibits neprilysin, a neutral endopeptidase that cleaves
natriuretic peptides such as atrial natriuretic peptide (ANP), brain natriuretic peptide
(BNP), and c-type natriuretic peptide (CNP), as well as certain vasoconstricting peptides
including as angiotensin I and II, and endothelin-1. Inhibition of neprilysin leads
to increased concentrations of endogenous natriuretic peptides, which function to
activate downstream receptors that promote vasodilation, natriuresis and diuresis,
while simultaneously increasing the concentration of vasoconstricting peptides such
as angiotensin II. Co-administration with valsartan, an angiotensin II receptor blocker,
prevents the vasoconstrictive effects of neprilysin inhibition and promotes a decrease
in vascular resistance and blood pressure.;
UNII : WB8FT61183;
InChIKey : ZASXKEGREHRXDL-CAWNUZPDSA-H;
CAS number : 936623-90-4;
Drug name : Entresto;
Molecule name : LCZ696; LCZ 696;
Origin ID : C162629;
UMLS CUI : C4033631;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
