Etalocib - CISMeF

Preferred Label : Etalocib;

NCIt synonyms : 2-[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenoxy]benzoic Acid; 2-[3-[3-[(5-Ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-2-propylphenoxy]benzoic Acid;

NCIt related terms : LY293111;

NCIt definition : A second-generation selective leukotriene B4 receptor (LTB4R) antagonist with potential antineoplastic activity. Although the exact underlying mechanism through which LY293111 exerts its effects has not been fully elucidated, this agent selectively binds to and blocks LTB4Rs, thereby inhibiting the downstream signalling pathway. LY29311 has been shown to induce apoptosis and inhibits cellular proliferation in LTB4R expressing cells, such as pancreatic cancer cells.;

Alternative definition : NCI-GLOSS: A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called leukotriene B4 receptor antagonists.;

UNII : THY6RIW44R;

InChIKey : YFIZRWPXUYFCSN-UHFFFAOYSA-N;

CAS number : 161172-51-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 161172-51-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : LY293111;

Chemical formula : C33H33FO6;

Codes from synonyms : 50603; CDR0000044981;

Details

Origin ID

C1626;

UMLS CUI

C0298617;

Automatic exact mappings (from CISMeF team)
- 2-(2-propyl-3-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenoxy)benzoic acid [MeSH concept]
- LY 293111 [MeSH concept]
- LY 293111 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 2-(2-propyl-3-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenoxy)benzoic acid [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Cisplatin/Gemcitabine/LY293111 [NCIt concept]

Keyword's position in hierarchy(ies) :

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