NCIt related terms : LUTETIUM (LU177) LILOTOMAB SATETRAXETAN;
NCIt definition : A radioconjugate consisting of lilotomab, a murine immunoglobulin G1 (IgG1) antibody
directed against the CD37 antigen, conjugated via the chelating agent 2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-tetraacetic
acid (p-SCN-Bn-DOTA) with potential antineoplastic activities. Upon administration
of lutetium Lu 177 lilotomab-satetraxetan, the lilotomab moiety binds to CD37 expressed
on certain tumor cells. Upon binding, lutetium Lu 177 lilotomab-satetraxetan delivers
a cytotoxic dose of beta radiation to CD37-expressing cells. CD37 is a transmembrane
glycoprotein expressed at high-levels on B-cells and to a lesser extent on T-cells
and myeloid cells, and is frequently overexpressed in certain B-cell lymphomas.;
CISMeF manual mappings