Preferred Label : Lutetium Lu 177 Lilotomab-satetraxetan;
NCIt synonyms : Lutetium Lu-177 Lilotomab Satetraxetan; 177Lu-Lilotomab-satetraxetan; 177Lu Lilotomab Satetraxetan; Lutetium Lu-177 Lilotomab-satetraxetan;
NCIt related terms : LUTETIUM (LU177) LILOTOMAB SATETRAXETAN;
NCIt definition : A radioconjugate consisting of lilotomab, a murine immunoglobulin G1 (IgG1) antibody
directed against the CD37 antigen, conjugated via the chelating agent 2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-tetraacetic
acid (p-SCN-Bn-DOTA) with potential antineoplastic activities. Upon administration
of lutetium Lu 177 lilotomab-satetraxetan, the lilotomab moiety binds to CD37 expressed
on certain tumor cells. Upon binding, lutetium Lu 177 lilotomab-satetraxetan delivers
a cytotoxic dose of beta radiation to CD37-expressing cells. CD37 is a transmembrane
glycoprotein expressed at high-levels on B-cells and to a lesser extent on T-cells
and myeloid cells, and is frequently overexpressed in certain B-cell lymphomas.;
UNII : 054ZP16K2Q;
CAS number : 1453362-90-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1453362-90-7
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G-SRS /a ;
Drug name : Betalutin;
NCI Metathesaurus CUI : CL446324;
Origin ID : C162565;
UMLS CUI : C5206649;
CISMeF manual mappings
- Semantic type(s)
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