Preferred Label : Lutetium Lu-177 Rituximab;
NCIt synonyms : 177Lu-Rituximab; Lutetium-177 Labeled Rituximab;
NCIt definition : A radioconjugate composed of rituximab, a recombinant chimeric murine/human immunoglobulin
G1 (IgG1) antibody directed against the CD20 antigen, conjugated to the beta-emitting
radioisotope lutetium Lu 177, with potential antineoplastic activity. Upon administration,
the rituximab moiety targets and binds to CD20 expressed on tumor cells and delivers
a cytotoxic dose of beta radiation to CD20-expressing cells. CD20 is expressed on
the surface of pre-B and mature B-lymphocytes and is overexpressed in a variety of
B-cell malignancies.;
NCI Metathesaurus CUI : CL971073;
Origin ID : C162563;
UMLS CUI : C5206647;
Semantic type(s)
- concept_is_in_subset
