Sitimagene Ceradenovec

Preferred Label : Sitimagene Ceradenovec;

NCIt definition : A replication-deficient adenovirus type 5 (Ad5) with E1 and partial E3 deletions containing cDNA for the herpes simplex virus thymidine kinase (HSV-Tk), which, when administered in combination with ganciclovir (GCV), possesses potential antineoplastic activity. Following administration, transgene-expressing cells produce thymidine kinase, which phosphorylates GCV to ganciclovir triphosphate, a cytotoxic nucleotide analog that is incorporated into DNA resulting in chain termination and induction of apoptosis in rapidly dividing cells. This process spares normal neurons as they do not proliferate and are therefore not susceptible to the toxic effects of GCV metabolites.;

CAS number : 898830-54-1;

Molecule name : EG 009; EG-009;

NCI Metathesaurus CUI : CL971128;

Details

Origin ID

C162553;

UMLS CUI

C2354637;

Automatic exact mappings (from CISMeF team)
- Sitimagene ceradenovec [ICD-11 More detail]
Currated CISMeF NLP mapping
- sitimagene ceradenovec [MeSH Supplementary Concept]
- sitimagene ceradenovec [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- sitimagene ceradenovec [ATC Code]
- sitimagene ceradenovec [MeSH Supplementary Concept]
- sitimagene ceradenovec [MeSH concept]
Validated automatic mappings to BTNT
- sitimagene ceradenovec [ATC Code]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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